RNA Technologies Expand Tool Kit for Cancer Immunotherapy
Elie Dolgin • October 1, 2019
Multiple companies are pursuing mRNA-based medicines that harness the body's protein-making machinery to transform lab-synthesized nucleotides into cancer-associated antigens, in the case of vaccines, or immune-stimulating molecules, in the case of therapeutics. Several candidates from BioNTech and Moderna have shown promise in early-stage testing.
In response to cellular stress, proteins become ensnared in chemical traffic jams, creating a kind of widespread sluggishness scientists call “proteolethargy.”
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